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Topography-Based Keratoconus Regression

Kymionis, George D. MD, PhD; Tsoulnaras, Konstantinos I. MD; Grentzelos, Michael A. MD; Shehadeh, Mohammad M. MD; Klados, Nektarios E. MD; Karavitaki, Alexandra A. MD; Kankariya, Vardhaman P. MD; Pallikaris, Ioannis G. MD, PhD

doi: 10.1097/ICO.0b013e318296e11d
Case Report

Purpose: To report 3 cases of keratoconic patients who had progressive corneal topographic flattening during a 2-year follow-up period.

Methods: Case series.

Results: Three patients with bilateral keratoconus, each operated for advanced keratoconus in one of their eyes, were observed for possible progression of the disorder for a period of 2 years. During the 2-year follow-up period, topographic examination showed progressive corneal flattening in the nonoperated eye. Mean keratometry decreased in all patients, whereas topography showed significant flattening at the apex of the cone. Best-spectacle-corrected visual acuity increased in one of the patients, whereas the others had stable uncorrected and best-spectacle-corrected visual acuity during the follow-up period. All patients had positive family medical history for diabetes mellitus, but none of them was diabetic.

Conclusions: This is the first report of topography-based keratoconus regression during a 2-year follow-up period.

*Vardinoyiannion Eye Institute of Crete, Department of Cornea, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece;

Cornea and Refractive Services, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL.

Reprints: George D. Kymionis, Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece (e-mail:

The authors have no funding or conflicts of interest to disclose.

Received February 14, 2013

Accepted April 12, 2013

Copyright © 2013 Wolters Kluwer Health, Inc. All rights reserved.