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Impact of the Cornea Donor Study on Acceptance of Corneas From Older Donors

Sugar, Alan MD; Montoya, Monty M. MBA; Beck, Roy MD, PhD; Cowden, John W. MD; Dontchev, Mariya MPH; Gal, Robin L. MSPH; Kollman, Craig PhD; Malling, Jackie BA, RN; Mannis, Mark J. MD; Tennant, Bradley BAFor the Cornea Donor Study Investigator Group

doi: 10.1097/ICO.0b013e31823f7550
Clinical Science

Purpose: To evaluate retrospectively whether the findings from the Cornea Donor Study (CDS) led to changes in the transplantation of corneas from older donors.

Methods: Eye banks in United States provided complete data on donor age and placement (domestic or international) for 86,273 corneas from 1998 to 2009. The data were analyzed by 3 periods, preceding CDS (1998–1999), during CDS (2000–2007), and after publication of CDS 5-year results (2008–2009), and separately for corneas placed within versus outside the United States.

Results: For corneal tissues transplanted in the United States, the percentage of donors who were 66 years or older increased from 19% before CDS to 21% during CDS and 25% after CDS (P < 0.001). Corresponding median (25th–75th percentile) donor ages were 53 (39–63), 54 (41–64), and 57 (46–66), respectively (P < 0.001). The opposite trend was observed for corneas distributed outside the United States, with the percentage of donors 66 years and older decreasing from 56% to 42% to 34%, respectively. Donor age trends over time varied by eye bank.

Conclusions: There was a modest overall increase in the donor age of corneas transplanted in the United States from 1998 to 2009, but the retrospective nature of the study limits our ability to attribute this change to the CDS. The modest increases in the donor age of corneas transplanted is a positive finding, but wider acceptance of older corneal donor tissue should be encouraged based on the 5-year evidence generated by the CDS.

*W.K. Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI

SightLife, Seattle, WA

Jaeb Center for Health Research, Tampa, FL

§Department of Ophthalmology, Mason Eye Institute, Columbia, MO

Minnesota Lions Eye Bank, Minneapolis, MN

Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, CA

**Midwest Eye-Banks, Ann Arbor, MI.

Reprints: Alan Sugar, Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647 (e-mail:

Supported by cooperative agreements with the National Eye Institute, National Institutes of Health, Department of Health and Human Services EY12728 and EY12358. Additional support provided by: Eye Bank Association of America, Bausch & Lomb, Inc, Tissue Banks International, Vision Share, Inc, San Diego Eye Bank, The Cornea Society, Katena Products, Inc, ViroMed Laboratories, Inc., Midwest Eye-Banks (Michigan Eye-Bank, Illinois Eye-Bank), Konan Medical Corp., Eye Bank for Sight Restoration, SightLife, Sight Society of Northeastern New York (Lions Eye Bank of Albany), Lions Eye Bank of Oregon.

Received August 12, 2011

Accepted October 25, 2011

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.