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The Comparison of the Effects of Latanoprost, Travoprost, and Bimatoprost on Central Corneal Thickness

Zhong, Yisheng MD; Shen, Xi MD; Yu, Jun MS; Tan, Haibo MS; Cheng, Yu MS

doi: 10.1097/ICO.0b013e3182000c27
Clinical Science

Purpose: To compare the effects of latanoprost, travoprost, and bimatoprost on central corneal thickness (CCT).

Methods: A total of 69 eyes of 69 patients with glaucoma or ocular hypertension submitted to monotherapy with prostaglandin analogues (latanoprost 0.005%, travoprost 0.004%, or bimatoprost 0.03%) during a mean of 17.19 ± 15.71 months follow-up period. Measurements were performed at the initial diagnosis and at the end of follow-up. All the measurements were carried out by the same doctor between 9 am and 11 am, using Goldmann applanation tonometer for intraocular pressure and ultrasonic pachymetry for CCT.

Results: A statistically significant reduction in CCT was observed in all groups (P < 0.001). The reduction of CCT in the latanoprost, travoprost, and bimatoprost groups was 14.95 ± 5.04, 15.73 ± 3.25, and 17.00 ± 6.23 μm, respectively. No significant difference was found in the reduction of CCT among the 3 groups (P > 0.05). No significant difference was also found in the reduction of CCT between the patients with less than or equal to 6 months' treatment and the patients with more than 6 months' treatment in the 3 groups (P > 0.05).

Conclusions: Topical therapy with prostaglandin analogues is associated with CCT reduction. Latanoprost, travoprost, and bimatoprost have a similar effect on CCT.

From the Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai, China.

Received for publication March 23, 2010; revision received August 6, 2010; accepted September 13, 2010.

Supported by Shanghai Leading Academic Discipline Project (No. S30205).

Y. Zhong and X. Shen contributed equally to this work.

The authors state that they have no proprietary interest in the products named in this article. The authors did not receive funding from any company.

Reprints: Yisheng Zhong, Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, 197 Ruijin No. 2 Road, 200025 Shanghai, China (e-mail:

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