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Deep Intrastromal Bevacizumab Injection for Management of Corneal Stromal Vascularization After Deep Anterior Lamellar Keratoplasty, A Novel Technique

Hashemian, Mohammad Naser MD; Zare, Mohammad Ali MD; Rahimi, Firoozeh MD; Mohammadpour, Mehrdad MD

doi: 10.1097/ICO.0b013e3181e291a6
Case Report

Purpose: To report the effect of intrastromal injection of bevacizumab in an eye with extensive corneal stromal vascularization after deep anterior lamellar keratoplasty.

Methods: Bevacizumab (2.5 mg/1 mL) was injected into the deep corneal stroma of an eye with severe and extensive stromal vascularization.

Results: Corneal vascularization regressed dramatically after deep stromal injection of bevacizumab with no recurrence after 6 months. Visual acuity was improved, and the patient's complaints subsided.

Conclusions: Corneal intrastromal injection of bevacizumab can be considered for management of intrastromal vascularization after deep anterior lamellar keratoplasty.

Supplemental Digital Content is available in the text

From the Cornea Department, Eye Research Center, Farabi Eye Center, Tehran Medical University, Qazvin Square, Tehran, Iran.

Received for publication May 18, 2009; revision received February 8, 2010; accepted February 17, 2010.

There is no financial interest for the authors in any methods or materials mentioned in this article.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (

Reprints: Mehrdad Mohammadpour, Cornea Department, Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran 55400010, Iran (e-mail:

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