Clinical SciencePenetrating Keratoplasty in Active Acanthamoeba KeratitisNguyen, Truc H MD; Weisenthal, Robert W MD; Florakis, George J MD; Reidy, James J MD; Gaster, Ronald N MD; Tom, Danita MDAuthor Information From the *Department of Ophthalmology, SUNY Upstate Medical University, Syracuse, NY; †Department of Ophthalmology, SUNY at Buffalo, Buffalo, NY; ‡Department of Ophthalmology, Columbia University, Harkness Eye Institute, New York, NY; and §Department of Ophthalmology, University of California, Irvine, CA. Received for publication December 10, 2008; revision received September 22, 2009; accepted November 23, 2009. This work received support from Research to Prevent Blindness and Lions District 20-Y1. Reprints: Truc H. Nguyen, SUNY Upstate Medical University, Department of Ophthalmology, 550 Harrison Street Suite 340, Syracuse NY 13202 (e-mail: [email protected]). Cornea: September 2010 - Volume 29 - Issue 9 - p 1000-1004 doi: 10.1097/ICO.0b013e3181cc79a1 Buy Metrics Abstract Purpose: To report the results of penetrating keratoplasty (PK) in active Acanthamoeba keratitis (AK). Methods: Nine patients with deep stromal infiltrates because of AK were treated with intensive antiamoebic medical therapy followed by PK during the acute infectious phase because of poor clinical response or poor compliance. Antiamoebic therapy was tapered after PK. Results: Visual acuity ranged from 20/15 to 20/50 after an average of 17 months after PK with no signs of recurrences. Patients had rapid resolution of symptoms. Conclusion: PK is a viable option for active AK not responding to maximum medical treatment. Copyright © 2010 Wolters Kluwer Health, Inc. All rights reserved.