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Contact Lens-Induced Regression of Lisch Epithelial Corneal Dystrophy

Lisch, Walter MD; Wasielica-Poslednik, Joanna MD; Lisch, Christina MD; Saikia, Parykshit MD; Pitz, Susanne MD

doi: 10.1097/ICO.0b013e3181aabefe
Case Report

Purpose: To describe the use of soft contact lenses (CL) to reduce the epithelial opacities of Lisch epithelial corneal dystrophy (LECD). First presentation of confocal microscopy in LECD.

Methods: Two unrelated female patients with LECD demonstrated a central gray opacity with distinct visual impairment. The first patient wore a daily hydroxyethlmethacrylate (HEMA) CL for 3 months and the second, a daily silicone hydrogel CL for 1 month. Pre-CL and post-CL appearances of the cornea were photodocumented at the slit lamp. Additionally, in the second patient, a confocal microscopic evaluation of LECD was performed.

Results: In both patients, the wearing of CL resulted in a distinct reduction of central corneal opacification with a visual improvement. Discontinued wearing of CL induced again a progression of opacity. The confocal microscopy disclosed the typical intracytoplasmatic vacuolization of the involved epithelial cells.

Conclusions: Wearing CL for a longer duration causes a significant regression of corneal opacities in LECD. The etiology of this phenomenon is interpreted as a CL-induced thinning of corneal epithelium and reduction of epithelial layers.

From the *Department of Ophthalmology, Klinikum Hanau, Hanau, Germany; and †Department of Ophthalmology, Johannes-Gutenberg-University Mainz, Mainz, Germany.

Received for publication November 9, 2008; revision received March 20, 2009; accepted April 16, 2009.

The authors state that they do not have any proprietary interest in this study.

Reprints: Walter Lisch, MD, Department of Ophthalmology, Klinikum Hanau, Leimenstrasse 20, D-63450, Hanau, Germany (e-mail:

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