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Inflammatory Corneal Neovascularization and Tissue Renin-Angiotensin System

Usui, Tomohiko MD, PhD; Ishida, Susumu MD, PhD; Amano, Shiro MD, PhD

doi: 10.1097/ICO.0b013e3181aea17d

Corneal neovascularization (NV), a severe sight-threatening condition affecting transparency of the cornea, is usually associated with inflammation and mainly results from inflammatory disruption of an exquisitely balanced corneal immune homeostasis. Although the renin-angiotensin system is chiefly known as the major controller of blood pressure, there is also an increasing body of evidence documenting the involvement of angiotensin II in inflammatory angiogenesis. To investigate the involvement of renin-angiotensin system in corneal NV, the expression of angiotensin II, angiotensinogen, and angiotensin type I receptor was examined in mouse suture-induced corneal NV model. Furthermore, we analyzed the expression of angiotensinogen and angiotensin-converting enzyme under hypoxic conditions in cultured corneal epithelium in vitro. The efficacy of angiotensin type I receptor blocker against corneal NV is discussed.

From the *Department of Ophthalmology, University of Tokyo Graduate School of Surgical Sciences, Tokyo, Japan; and †Department of Ophthalmology, Keio University, Tokyo, Japan.

Reprints: Tomohiko Usui, MD, PhD, Department of Ophthalmology, University of Tokyo Graduate School of Surgical Sciences, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan (e-mail:

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