To report 4 cases of flap margin-related corneal ulcer
that developed 5 years after laser in situ keratomileusis (LASIK
We retrospectively documented the clinical and laboratory characteristics of all patients between 2004 and 2008 who presented with LASIK
-related corneal ulcer
that appeared >5 years postoperatively. The 4 patients who had this condition were 25-, 33-, 61-, and 62-year-old males.
Two patients had cultures positive to Staphylococcus aureus
and Streptococcus epidermidis
. Two ulcers healed after standard fortified topical antibiotic regimen, 1 ulcer healed after treatment with moxifloxacin, and the fourth healed after treatment with lomefloxacin. All cases presented 5 years after the LASIK
procedures can be associated with the risk of corneal infection even years later. The mechanism may be flap margin instability causing epithelial defense barrier disturbance.