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Salzmann Nodules-A Possible New Ocular Manifestation of Crohn's Disease: A Case Report

Lange, Alex P MD; Bahar, Irit MD; Sansanayudh, Wiwan MD; Kaisermann, Igor MD, MSc, MHA; Slomovic, Allan R MA, MD, FRCSC

doi: 10.1097/ICO.0b013e3181814c90
Case Report

Purpose: The purpose of this article was to describe an association between Salzmann nodules and Crohn's disease.

Methods: Single observational case report.

Results: Multiple bilateral Salzmann nodules were found in a 50-year-old woman with inactive Crohn's disease. Her visual acuity was 20/25 in OD and 20/20 in OS because of involvement of the midperipheral cornea. Intraocular pressure was significantly elevated in both eyes. However, there were no other signs of glaucoma. The rest of the ocular examination was unremarkable.

Conclusions: Salzmann nodules may represent a distinct clinical sign of ocular involvement in Crohn's disease.

From the *Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada; and †Department of Ophthalmology, Barzilai Medical Center, Ashkelon, Israel.

Received for publication December 14, 2007; revision received May 23, 2008; accepted May 24, 2008.

Reprints: Alex P. Lange, MD, Department of Ophthalmology, Toronto Western Hospital, 399 Bathurst Street, Ontario, Canada M5T 2S8 (e-mail:

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