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Combined Use of Superficial Keratectomy and Subconjunctival Bevacizumab Injection for Corneal Neovascularization

Qian, Cynthia Xin-ya MD; Bahar, Irit MD; Levinger, Eliya MD; Rootman, David MD, FRCSC

doi: 10.1097/ICO.0b013e31817c41e3
Case Report

Purpose: To report the effect of superficial keratectomy combined with subconjunctival bevacizumab injection in 2 cases of corneal neovascularization (NV).

Methods: An interventional case series was undertaken on 2 patients with corneal NV: 1 due to sclerokeratitis secondary to rheumatoid arthritis and the other due to Terrien marginal degeneration. Both patients underwent superficial keratectomy combined with subconjunctival bevacizumab injection (2.5 mg/0.1 mL).

Results: Corneal NV regressed with the surgical removal and showed no signs of recurrence after 3 months of follow-up. Both patients reported dramatic subjective improvement in their vision within 1-2 weeks. Best corrected visual acuity improved in 1 patient.

Conclusion: The combination of superficial keratectomy with subconjunctival injection of bevacizumab may offer a new strategy for the treatment of superficial corneal NV.

From the *Department of Ophthalmology, University of Montreal, Montreal, Quebec, Canada; and †Department of Ophthalmology, Toronto Western Hospital, Toronto Ontario, Canada.

Received for publication November 16, 2007; revision received March 23, 2008; accepted April 14, 2008.

Reprints: Cynthia Xin-ya Qian, Department of Ophthalmology, University of Montreal, Hôspital Notre-Dame-CHUM (Centre Hospitalier Universitaire de Montreal), 1560, sherbrooke street E, Montreal, Quebec, H2L 4M1 (e-mail:

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