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Diagnosis of Multiple Myeloma in a Patient With Atypical Corneal Findings

Nakatsukasa, Mina MD*; Sotozono, Chie MD, PhD*; Tanioka, Hidetoshi MS*; Shimazaki, Chihiro MD, PhD; Kinoshita, Shigeru MD, PhD*

doi: 10.1097/ICO.0b013e31815b82cd
Case Report

Purpose: To report the case of a 67-year-old woman with a diagnosis of multiple myeloma (MM) and atypical corneal opacity as the first appearance.

Methods: The patient consulted an ophthalmologist regarding blurred vision that progressed gradually without any systemic symptoms. The corneal epithelium and anterior stroma of both eyes harbored diffuse gray-white deposits of unknown etiology. She underwent a general checkup that included molecular genetic analysis. At cataract surgery, performed 5 months after the diagnosis, the corneal epithelium was removed with an epikeratome. The epithelial sheet was analyzed histologically.

Results: Her serum immunoglobulin G (IgG) level was increased; serum immunoelectrophoresis showed a monoclonal γ-globulin spike of the IgG κ-type. The presence of 30.4% pleomorphic plasma cells in the bone marrow confirmed the diagnosis of MM. Her visual acuity improved after combined cataract surgery and superficial keratectomy. The surgically removed epithelial sheet showed IgG deposits in the corneal epithelium; electron-dense intracellular deposits were observed in corneal epithelial cells.

Conclusions: In some individuals, unusual corneal deposits may constitute the first sign of MM. Superficial keratectomy with an epikeratome is a minimally invasive treatment of MM with corneal opacification.

From the *Department of Ophthalmology and the †Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Received for publication April 9, 2007; revision received September 4, 2007; accepted September 16, 2007.

Supported in part by grants-in-aid for Translational Research and Scientific Research from the Japanese Ministry of Education, Culture, Sports, and Science and Technology, and grants from the Japanese Ministry of Health, Labor, and Welfare.

Reprints: Mina Nakatsukasa, Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-0841, Japan (e-mail:

© 2008 Lippincott Williams & Wilkins, Inc.