ReviewReview of Corneal Endothelial Specular Microscopy for FDA Clinical Trials of Refractive Procedures, Surgical Devices, and New Intraocular Drugs and SolutionsMcCarey, Bernard E PhD*; Edelhauser, Henry F PhD*; Lynn, Michael J MS†Author Information From the *Department of Ophthalmology and †Department of Biostatistics, Emory University, Atlanta, GA. Received for publication February 14, 2007; revision received August 1, 2007; accepted August 10, 2007. Supported in part by National Institutes of Health Grants R01-EY00933 and P30-EY06360 and an unrestricted grant from Research to Prevent Blindness. Reprints: Bernard E. McCarey, Emory University Eye Center, 1365B Clifton Road, Suite B2600, Atlanta, GA 30322 (e-mail: [email protected]). Cornea: January 2008 - Volume 27 - Issue 1 - p 1-16 doi: 10.1097/ICO.0b013e31815892da Buy Metrics Abstract Specular microscopy can provide a noninvasive morphologic analysis of the corneal endothelial cell layer from subjects enrolled in clinical trials. The analysis provides a measure of the endothelial cell physiologic reserve from aging, ocular surgical procedures, pharmaceutical exposure, and general health of the corneal endothelium. The purpose of this review is to discuss normal and stressed endothelial cell morphology, the techniques for determining the morphology parameters, and clinical trial applications. © 2008 Lippincott Williams & Wilkins, Inc.