Case ReportSlit-lamp, Confocal, and Light Microscopic Findings of Corneal SiderosisWitherspoon, S Robert MD; Hogan, R Nick MD, PhD; Petroll, W Matthew PhD; Mootha, V Vinod MDAuthor Information From the University of Texas Southwestern Medical Center, Dallas, TX. Received for publication September 15, 2006; revision received June 13, 2007; accepted June 16, 2007. Supported by an unrestricted Grant and Lew R. Wasserman Merit Award (WMP) from Research to Prevent Blindness, New York, and NIH Infrastructure Grant EY16664. Reprints: V. Vinod Mootha, Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9057 (e-mail: [email protected]). Cornea: December 2007 - Volume 26 - Issue 10 - p 1270-1272 doi: 10.1097/ICO.0b013e318145330b Buy Metrics Abstract Purpose: To report the clinical, histopathologic, and confocal findings of corneal siderosis. Methods: A 35-year-old man presented after a car battery explosion with diffuse left corneal anterior stromal pigment deposition and an intraocular metallic foreign body of the left iris. The corneal pigment was analyzed by confocal microscopy and a lamellar corneal biopsy. Results: Confocal microscopy showed the pigment to be highly reflective material in the corneal stroma with greatest density anteriorly. Histologic examination revealed the pigment to be iron with a diagnosis consistent with corneal siderosis. Conclusions: Corneal biopsy with Prussian blue established siderosis as the etiology of corneal pigmentation. A short delay in the removal of the foreign body contributed to the development of siderosis. The location of the foreign body on the iris may account for the predominant corneal involvement and relative sparing of the retina. Confocal microscopy may be useful in the evaluation of corneal siderosis. © 2007 Lippincott Williams & Wilkins, Inc.