Clinical ScienceEfficacy of Intracameral Amphotericin B Injection in the Management of Refractory Keratomycosis and EndophthalmitisYilmaz, Safiye MD; Ture, Melih MD; Maden, Ahmet MDAuthor Information From the Department of Ophthalmology, İzmir Atatürk Training and Research Hospital, İzmir, Turkey. Received for publication August 12, 2006; revision received November 6, 2006; Accepted November 21, 2006. Reprints: Safıye Yilmaz, M.Kemal Cad. No: 36/4 35040, Bornova, İzmir, Turkey (e-mail: email@example.com). Cornea: May 2007 - Volume 26 - Issue 4 - p 398-402 doi: 10.1097/ICO.0b013e318030767e Buy Metrics Abstract Purpose: To evaluate the efficacy of intracameral amphotericin B injection in the adjunctive management of keratomycosis with probable intraocular extension not responding to conventional antifungal therapy. Methods: Fourteen eyes of 12 patients with fungal keratitis that did not respond to initial treatment with topical and intravenous fluconazole and oral itraconazole were treated with up to 5 intracameral injections of 5 μg of amphotericin B. Six eyes received one injection, and 8 required subsequent injections. Results: Twelve eyes responded to amphotericin B therapy, including 5 that healed with a central corneal scar and 8 that healed with a peripheral opacity. Two eyes progressed to evisceration. Four eyes developed anterior subcapsular cataract after intracameral amphotericin B. Conclusions: Intracameral amphotericin B may be an effective adjunctive treatment of fungal keratitis unresponsive to conventional antifungal therapy, although cataract may occur. © 2007 Lippincott Williams & Wilkins, Inc.