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Descemet-Stripping Automated Endothelial Keratoplasty

Gorovoy, Mark S MD

doi: 10.1097/01.ico.0000214224.90743.01
Clinical Science

Purpose: To evaluate the speed of visual recovery in 16 consecutive patients with corneal endothelial dysfunction who received Descemet-stripping automated endothelial keratoplasty (DSAEK).

Methods: This is a retrospective study of a novel method for small-incision endothelial transplantation (DSAEK). Endothelial replacement was accomplished with Descemet stripping of the recipient and insertion of a posterior donor tissue that had been prepared with a microkeratome. Best spectacle-corrected visual acuity (BSCVA) by manifest refraction, endothelial counts, and dislocation rates were measured up to 12 months after DSAEK.

Results: Sixteen consecutive patients underwent uncomplicated DSAEK. Three patients had known optic nerve or macular disease precluding vision better than 20/200. Of the remaining 14 patients, 11 had BSCVA of 20/40 by postoperative week 12 (7 by week 6). The remaining 2 were 20/50 by weeks 6 and 12. All 14 patients were 20/40 or better at 1 year. One patient had a primary graft failure, and surgery was repeated with 20/40 BSCVA at 1 year. The dislocation rate was 25%. The average cell count between 7 and 10 months was 1714. The average pachymetry was 682.

Conclusion: DSAEK surgery allows rapid, excellent BSCVA visual recovery. The rate of visual recovery is more rapid than usually found with penetrating keratoplasty.

From Gorovoy M.D. Eye Specialists, Ft Myers, FL.

Received for publication May 17, 2005; revision received October 19, 2005; accepted October 27, 2005.

Supported in part by Moria.

Reprints: Mark S. Gorovoy, MD, Eye Specialists, 12381 S. Cleveland Avenue, Suite 300, Ft Myers, FL 33907 (e-mail:

© 2006 Lippincott Williams & Wilkins, Inc.