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Avellino Corneal Dystrophy Exacerbated After LASIK: Scanning Electron Microscopic Findings

Roh, Mi In MD*; Grossniklaus, Hans E. MD; Chung, So-Hyang MD*; Kang, Shin Jeong MD; Kim, Woon Cho MD; Kim, Eung Kweon MD

doi: 10.1097/01.ico.0000183536.07275.9a
Clinical Sciences

Purpose: To evaluate the ultrastructure of the cornea of Avellino corneal dystrophy (ACD) exacerbated by LASIK.

Methods: Three ACD patients with exacerbation of granular corneal deposits after LASIK underwent surgical removal of the corneal flap. The corneal flap was processed for scanning electron microscopy (SEM).

Results: SEM of all patients showed abnormal granular clusters in the fibrils of the corneal flap.

Conclusion: Laser in situ keratomileusis induces corneal collagen abnormalities and adhesions of granular material in ACD patients.

From the *Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea; †Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA; ‡Emory University, Atlanta, GA; and §The Brain Korea 21 Project for Medical Science, Yonsei University, Seoul, Korea. Received for publication March 8, 2005; revision received July 6, 2005; accepted July 13, 2005.

Received for publication March 8, 2005; revision received July 6, 2005, accepted July 13, 2005.

This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (A050554).

Reprints: Eung Kweon Kim, MD, Severance Hospital, Yonsei University College of Medicine Department of Ophthalmology, #134 Shinchon-dong, Seodaemun-ku, 120-752 Seoul Korea (e-mail:

© 2006 Lippincott Williams & Wilkins, Inc.