To evaluate the ultrastructure of the cornea of Avellino corneal dystrophy (ACD) exacerbated by LASIK.
Three ACD patients with exacerbation of granular corneal deposits after LASIK underwent surgical removal of the corneal flap. The corneal flap was processed for scanning electron microscopy (SEM).
SEM of all patients showed abnormal granular clusters in the fibrils of the corneal flap.
Laser in situ keratomileusis induces corneal collagen abnormalities and adhesions of granular material in ACD patients.
From the *Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea; †Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA; ‡Emory University, Atlanta, GA; and §The Brain Korea 21 Project for Medical Science, Yonsei University, Seoul, Korea. Received for publication March 8, 2005; revision received July 6, 2005; accepted July 13, 2005.
Received for publication March 8, 2005; revision received July 6, 2005, accepted July 13, 2005.
This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (A050554).
Reprints: Eung Kweon Kim, MD, Severance Hospital, Yonsei University College of Medicine Department of Ophthalmology, #134 Shinchon-dong, Seodaemun-ku, 120-752 Seoul Korea (e-mail: email@example.com).