Clinical SciencesThe Relation of Conjunctival and Corneal Findings in Severe Ocular AllergiesTanaka, Mari MD; Dogru, Murat MD; Takano, Yoji MD; Miyake-Kashima, Minori MD; Asano-Kato, Naoko MD; Fukagawa, Kazumi MD; Tsubota, Kazuo MD; Fujishima, Hiroshi MDAuthor Information From the Department of Ophthalmology, Tokyo Dental College, Chiba, Japan. Received for publication July 15, 2003; revision received December 10, 2003; accepted December 10, 2003. This paper was presented at the 2002 ARVO Meeting, Fort Lauderdale, FL, USA. Reprints: Mari Tanaka, MD, Department of Ophthalmology, Tokyo Dental College, 5-11-13 Sugano, Ichikawa, Chiba 272-8513, Japan (e-mail: [email protected]). Cornea: July 2004 - Volume 23 - Issue 5 - p 464-467 doi: 10.1097/01.ico.0000114836.13127.45 Buy Metrics Abstract Objective: Corneal lesions such as ulcers and erosions are major complications observed in patients with severe ocular allergic diseases. We aimed to look into the relationship between specific clinical conjunctival findings and the severity of corneal complications. Methods: Thirty eyes of 6 patients with vernal keratoconjunctivitis (VKC) and 13 patients with atopic keratoconjunctivitis (AKC) were evaluated in this study. Slit-lamp photographs of upper tarsal conjunctiva and cornea were used to evaluate the clinical findings objectively. The corneal findings and clinical findings of upper tarsal conjunctiva such as conjunctival injection, edema, the height of papillae, and mucous discharge were evaluated and graded. Statistical correlations between conjunctival findings and the severity of corneal damage were analyzed. Results: Conjunctival injection and edema significantly correlated with the severity of corneal complications. The height of the papillae and the amount of mucous discharge did not correlate with the severity of corneal complications. Conclusion: Direct signs of inflammation such as injection and edema correlated with corneal damage. The height of papillae did not show a significant correlation with the corneal findings. Our results suggest that inflammation of the conjunctiva rather than mechanical factors may play a greater role in the formation of corneal damage in severe ocular allergies. © 2004 Lippincott Williams & Wilkins, Inc.