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Photodynamic Therapy of Corneal Neovascularization with Verteporfin

Fossarello, Maurizio MD; Peiretti, Enrico MD; Zucca, Ignazio MD; Serra, Antonina MD

Case Reports

Purpose. To describe the effect of photodynamic therapy (PDT) using verteporfin (Visudyne®) on corneal neovascularization (CNV) in two patients.

Methods. Two patients with corneal neovascularization were treated with a nonthermal laser light at 689 nm delivered 15 min after an intravenous infusion of verteporfin. Postoperative outcome of neovascularization was followed clinically (inflammation, intraocular pressure, and visual acuity) and photographically [color photographs and corneal fluorescein and indocyanine green (ICG) angiography] for a minimum of 6 months.

Results. Successful photothrombosis of corneal neovascularization was obtained immediately after treatment in the two patients, and regression was verified by corneal fluorescein and ICG angiography. In one case, partial vessel recanalization was observed after 1 month, and treatment was repeated, with complete regression of new vessels. No relevant side effects were observed in our cases.

Conclusions. PDT with verteporfin is an effective and safe procedure indicated for patients with corneal neovascularization; however, multiple sessions may be required.

From the Department of Surgical Sciences, Eye Clinic, University of Cagliari, I-09124 Cagliari, Italy.

Submitted December 3, 2002.

Revision received March 27, 2003.

Accepted March 29, 2003.

The authors have no proprietary or financial interest in any products or techniques described in this article.

Address correspondence and reprint requests to Maurizio Fossarello, University Eye Clinic, Ospedale San Giovanni di Dio, I-09124 Cagliari, Italy. E-mail:

© 2003 Lippincott Williams & Wilkins, Inc.