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Keratitis Caused by Verticillium Species

Shin, Jae-Yong M.D.; Kim, Hyo-Myung M.D.; Hong, Jong-Wook M.D.; Dragicevich, John M.D.

Case Reports

Purpose. To report a case of fungal keratitis caused by Verticillium species.

Methods. A 50-year-old man developed pain, redness, and an infiltrate in his left eye and had no history of trauma. The cornea showed superficial, white, stromal infiltrates and epithelial ulceration with a dendritic margin. The clinical features suggested herpetic keratitis, and the patient was treated with topical antiviral medication. Two weeks later, his condition deteriorated. Examination of the left eye showed stromal infiltrates with a feathery margin and epithelial ulceration with its covering white exudates. Corneal scrapings were taken for direct microscopic examination and culture.

Results. Corneal scraping showed the presence of fungal filaments. The fungus was identified as Verticillium species. Topical amphotericin B and systemic fluconazole were started after discontinuing the antiviral treatment. Clinically, the inflammation subsided during the 3 weeks after treatment.

Conclusion. This is a rare case of infectious keratitis caused by Verticillium species. Rare species of fungal infection should be considered in the differential diagnosis of stromal keratitis refractive to conventional medical treatment.

From the Department of Ophthalmology, Korea University Hospital, Korea University Medical College, Seoul, Korea.

Submitted April 25, 2001.

Revision received October 2, 2001.

Accepted October 4, 2001.

Address correspondence and reprint requests to Dr. J.-W. Hong, Department of Ophthalmology, Korea University Guro Hospital, 80 Guro-dong, Guro-gu, Seoul, 152-705, Korea. E-mail:

© 2002 Lippincott Williams & Wilkins, Inc.