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Exacerbation of Avellino Corneal Dystrophy After Laser In Situ Keratomileusis

Wan, Xiu Hua M.D.; Lee, Hyun Chae M.S.; Stulting, R. Doyle M.D., Ph.D.; Kim, Terry M.D.; Jung, Seung Eun M.S.; Kim, Moon Jung M.D.; Kim, Eung Kweon M.D., Ph.D.

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Purpose. To report a case of Avellino corneal dystrophy that increased in severity 1 year after uncomplicated laser in situ keratomileusis (LASIK) for myopia.

Methods. Avellino dystrophy was confirmed by polymerase chain reaction sequencing of DNA from the patient and her parents.

Results. Best spectacle-corrected visual acuity decreased from 20/20 to 20/30 12 to 20 months after LASIK owing to opacities that appeared centrally in the corneal stroma and the LASIK flap and remaining posterior stroma interface.

Conclusions. LASIK is contraindicated in patients with Avellino corneal dystrophy because vision may be reduced by corneal opacities that appear in the interface of the flap and remaining posterior stroma postoperatively.

From the Institute of Vision Research, Department of Ophthalmology (X.H.W., H.C.L., S.E.J., M.J.K., E.K.K.), Yonsei University College of Medicine, Seoul, Korea; the Department of Ophthalmology (X.H.W.), Second Hospital, Zhejiang University College of Medicine, Hangzhou, China; the Brain Korea 21 Project for Medical Science (S.E.J., E.K.K.), Yonsei University, Seoul, Korea; the Department of Ophthalmology (R.D.S.), Emory University School of Medicine, Atlanta, Georgia; and the Department of Ophthalmology (T.K.), Duke University School of Medicine, Durham, North Carolina, U.S.A.

Submitted July 17, 2001.

Revision received November 6, 2001.

Accepted November 20, 2001.

The authors have no proprietary interests in this study.

This work was supported by Yonsei University Research Fund of 2000.

Address correspondence and reprint requests to Dr. E.K. Kim, Department of Ophthalmology, Yonsei University College of Medicine, Brain Korea 21 Project for Med Science, CPO Box 8044, Seoul 120-752, Korea. E-mail: eungkkim@yumc.yonsei.ac.kr

© 2002 Lippincott Williams & Wilkins, Inc.