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Treatment of Superior Limbic Keratoconjunctivitis by Application of Autologous Serum

Goto, Eiki M.D.; Shimmura, Shigeto M.D.; Shimazaki, Jun M.D.; Tsubota, Kazuo M.D.

Clinical Sciences

Purpose. To determine the efficacy of autologous serum drops in the treatment of superior limbic keratoconjunctivitis (SLK).

Methods. Twenty-two eyes of 11 patients were diagnosed with SLK. All eyes were treated with 20% diluted autologous serum eyedrops 10 times a day in addition to ongoing treatment of dry eye. Fluorescein and rose bengal staining scores, as well as subjective symptom gradings, were performed before and after 4 weeks of therapy.

Results. Nine of the 11 patients responded well to treatment (82%). The average rose bengal and fluorescein score improved (p < 0.05), and there was subjective improvement.

Conclusion. Autologous serum application can be used as an alternative mode of therapy in SLK.

From the Department of Ophthalmology, Tokyo Dental College, Ichikawa City, Chiba (E.G., S.S., J.S., K.T.); and the Department of Ophthalmology, Keio University School of Medicine, Tokyo (E.G., S.S., K.T.), Japan.

Submitted February 1, 2001.

Revision received June 11, 2001.

Accepted June 14, 2001.

Grants: Support was obtained in the form of a grant from the Japanese Ministry of Education, Tokyo, Japan, and a grant from the Hightech Research Center at Tokyo Dental College, Chiba, Japan. Support was also received from the Medical School Faculty and Alumni Grants of Keio University Medical School, Tokyo, Japan.

Address correspondence and reprint requests to Dr. K. Tsubota, Department of Ophthalmology, Tokyo Dental College, 11-13 Sugano, 5 Chome, Ichikawa-shi, Chiba 272-8513, Japan. E-mail:

© 2001 Lippincott Williams & Wilkins, Inc.