Case ReportsPeripheral Nonulcerative Keratitis as a Presenting Sign of Microscopic PolyangiitisDarlington, Jason K. B.S.; Mannis, Mark J. M.D.; Segal, William A. M.D.; Feiz, Vahid M.D.; Klug, Donald E. M.D. Author Information From the Department of Ophthalmology (J.K.D., M.J.M., W.A.S.), University of California, Davis, California, U.S.A.; and the Department of Ophthalmology (V.F.), University of Arkansas, Little Rock, Arkansas, U.S.A. Submitted October 16, 2000. Revision received January 16, 2001. Accepted January 30, 2001. Grants: Supported by an unrestricted grant from Research to Prevent Blindness, New York, New York. Address correspondence and reprint requests to Dr. M.J. Mannis, Department of Ophthalmology, 4860 Y Street, Suite 2400, Sacramento, CA 95817, U.S.A. Cornea: July 2001 - Volume 20 - Issue 5 - p 522-524 Buy Abstract Purpose. To report a 16-year-old woman who had peripheral keratitis as a presenting sign of microscopic polyangiitis (MPA), which rapidly progressed to acute renal failure. Method. Case report. Results. The patient's vasculitis was diagnosed by renal biopsy, which was evaluated with histologic, immunofluorescence, and electron microscopy. The diagnosis was confirmed by laboratory study, which showed a positive antimyeloperoxidase antibody. Conclusion. MPA may rarely present with ocular findings and should be considered in the differential diagnosis when a patient has peripheral keratitis. © 2001 Lippincott Williams & Wilkins, Inc.