Original Articles: PDF OnlyOcular Surface Residence Times of Artificial Tear SolutionsSnibson, G R F.R.A.C.S1; Greaves, J L B.Sc2; Soper, N D W M.Sc.3; Tiffany, J M Ph.D.1; Wilson, C G Ph.D.2; Bron, A J F.C.Ophth.1Author Information 1From the Department of Ophthalmology, University of Oxford, Oxford, England 2Department of Physiology and Pharmacology, University of Nottingham, Oxford, England 3Department of Nuclear Medicine, John Radcliffe Hospital Oxford, England Cornea: July 1992 - Volume 11 - Issue 4 - p 288-293 Buy Abstract Solutions of hydroxypropylmethylcellulose (HPMC) and polyvinyl alcohol (PVA) are widely used as artificial tears. However, their usefulness is limited by the short duration of their effect. Dilute sodium hyaluronate (SH) solutions exhibit non-Newtonian rheology with high viscosities at low shear rates, which would be expected to enhance their ocular surface residence time. Using quantitative 7 scintigraphy, estimates of the ocular surface residence times of 0.3% HPMC, 1.4% PVA, and 0.2% SH were made in six patients with keratoconjunctivitis sicca. The sodium hyaluronate solution had a mean half-life on the ocular surface of 321 s, significantly longer than hydroxypropylmethylcellulose (44 s; p=0.012) and polyvinyl alcohol (39 s; p=0.013). © Lippincott-Raven Publishers.