Original Articles: PDF OnlyTopical Ofloxacin in the Treatment of Pseudomonas Keratitis in a Rabbit ModeGritz, David C. M.D.1; McDonnell, Peter J. M.D.1; Lee, Tae Y. M.D.1; Tang-Liu, Diane Ph.D.2; Hubbard, Bradley B. M.D.2; Gwon, Arlene M.D.2 Author Information 1From the Doheny Eye Institute and the Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles, California, U.S.A 2From the Allergan Pharmaceuticals, Irvine, California, U.S.A Cornea: March 1992 - Volume 11 - Issue 2 - p 143-147 Buy Abstract Ofloxacin, a new quinolone antibiotic with a broad spectrum of activity, is very effective against Pseudomonas aeruginosa in vitro. Its effectiveness was studied in a rabbit model of tobramycin-sensitive P. aeruginosa. Treatment groups received either vehicle, tobramycin 0.3%, or ofloxacin 0.3%. Twelve hours of treatment decreased the bacterial counts from a mean of 2.2 ± 0.7 x 106 colony forming units (cfu) per cornea in the vehicle group to means of 513 ± 670 and 435 ± 524 cfu in the tobramycin and ofloxacin groups, respectively. This decrease in bacterial counts was statistically significant (p=0.001 for tobramycin and ofloxacin each compared with control, p=0.86 for tobramycin compared with ofloxacin). After seven days, all antibiotic-treated corneas were sterile and the epithelial defects healed at comparable rates. Aqueous humor drug levels were higher in infected eyes without an intact epithelium (p=0.02); in eyes with intact epithelium, concentrations of ofloxacin were higher than were those of tobramycin (p=0.002). In this animal model, ofloxacin proved to be an effective antibiotic with no evidence of toxicity. Copyright © 1992 Wolters Kluwer Health, Inc. All rights reserved.