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Mendelsohn Alan D. M.D.; Stock, E. Lee M.D.; Schneck, Gideon L. M.D.; Siel, Janet M. M.D.; Mendelsohn, Sara L. B.A.; Reddy, Chittaranjan M.D.
Cornea: 1986
Original Article: PDF Only

Argon laser photocoagulation, topical steroid application, and elimination of cholesterol from the diet were surveyed as treatment modalities for lipid keratopathy. Corneal neovascularization was induced by insertion of sutures in the eyes of rabbits, which were rendered hypercholesterolemic through cholesterol feeding. Lipid deposition ensued at the sites of neovascularization, creating an experimental model of lipid keratopathy. During the course of the investigation the corneal sutures remained intact. Serum cholesterol, cholesterol content of the enucleated corneas, and density and extent of lipid deposits were monitored. Under the conditions employed, laser surgery had a deleterious effect, topical corticosteroids produced a slightly therapeutic effect, and removal of cholesterol from the rabbits' diet had a marked beneficial effect in reducing the corneal cholesterol content.

© Lippincott-Raven Publishers.