Message from the Editor: PDF OnlySerdarevic Olivia N. M.D.; Goichot-Bonnat, L. M.D.; Foster, Jorge O. M.D.; Boscher, Claude M.D.; Patey, Agnes M.S.; Savoldelli, Michele M.S.; Renard, Gilles M.D.; Pouliquen, Yves M.D.Cornea: 1986 - p 47-54 Buy Abstract The increasing use of topical cyclosporin A in the treatment of corneal allograft reaction and of external immune disease has made it necessary to investigate its possible corneal epithelial toxicity. We performed masked, controlled rabbit studies in 40 eyes to compare the effect of topical application of 2% cyclosporin A, its solvent (castor oil), and balanced salt solution on reepithelialization of iodine vapor-produced epithelial defects and on subsequent maintenance of an intact corneal surface. The rate of defect closure was measured by image analysis of standardized photographs. Statistical analysis revealed no difference between groups in healing rates and in the amount of superficial punctate epithelial erosion for up to 6 days after reepithelialization; superficial punctate epithelial erosion was extremely rare in all groups from 6 days up to 8 weeks. Light microscopy, scanning electron microscopy, and transmission electron microscopy examination 12 days following defect closure showed no difference in epithelial and stromal morphology. Thus we were unable to demonstrate any corneal epithelial toxicity of 2% cyclosporin A. © Lippincott-Raven Publishers.