External Diseas: PDF OnlyAcanthamoeba Keratitis Successfully Treated with Penetrating Keratoplasty Suggested Immunogenic Mechanisms of ActionBlackman, H. Jane M.D.; Rao, Narsing A. M.D.; Lemp, Michael A. M.D.; Visvesvara, Govina S. Ph.D.Author Information Department of Ophthalmology, Georgetown University School of Medicine, Washington, D.C. (HJB, MAL); Centers for Disease Control, Atlanta, Georgia (GSV); and Doheny Eye Foundation, Los Angeles, California (NAR) Cornea: June 1984 - Volume 3 - Issue 2 - p 125-130 Buy Abstract A patient with a corneal ulcer caused by Acanthamoeba polyphaga has been successfully treated with a penetrating keratoplasty. The pathologic specimen showed no inflammatory infiltrate surrounding the intact amoeba, whereas necrotic organisms were surrounded by an intense cellular reaction. Indirect immunochemical studies showed that the trophozoite stained profusely, but the cyst form exhibited the antigenic site on the cyst wall. © Lippincott-Raven Publishers.