This collection contains Practice Issues articles published in Continuum. In addition to the lifelong learning of new clinical and scientific knowledge, neurologists must understand the constantly evolving environment in which they practice. Changes occur rapidly in reimbursement and regulatory areas, in the integration of evidence-based medicine, and in the implementation of patient safety measures into clinical practice. Each article, written by neurologists with particular experience in systems-based practice and practice-based learning and improvement, present case-based examples of one of these issues as it relates to the clinical topic of the issue in which it was published.