Peter J. Goadsby, MD, PhD, Guest Editor
Director, National Institute for Health Research and Wellcome Trust King’s Clinical Research Facility; Professor of Neurology, King’s College London, London, United Kingdom
Relationship Disclosure: Dr Goadsby has received personal compensation for consulting, speaking engagements, and serving on the scientific advisory boards of Alder BioPharmaceuticals, Inc; Allergan; Amgen Inc; Autonomic Technologies, Inc; Dr. Reddy’s Laboratories Ltd; ElectroCore, LLC; Eli Lilly and Company; eNeura Inc; Novartis AG; Scion Pharmaceuticals, Inc; Teva Pharmaceutical Industries Ltd; and Trigemina, Inc. Dr Goadsby has received personal compensation as an editor for MedicoLegal Investigations Ltd; NEJM Journal Watch; UpToDate, Inc; and Wolters Kluwer and receives royalties from Oxford University Press. Dr Goadsby has received grants from Amgen Inc and Eli Lilly and Company. Dr Goadsby holds a patent on magnetic stimulation for headache with eNeura Inc without fee.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Goadsby reports no disclosure.
Pyari Bose, MD, MRCP
Neurologist, Headache Group, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology, and Neuroscience; National Institute for Health Research and Wellcome Trust King’s Clinical Research Facility, King’s College London, London, United Kingdom
Relationship Disclosure: Dr Bose has received personal compensation as a speaker for Teva Pharmaceutical Industries Ltd and has received research/grant funding from The Migraine Trust Clinical Training Fellowship.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Bose reports no disclosure.
Mark Burish, MD, PhD
Assistant Professor, Department of Neurosurgery; Director, Will Erwin Headache Research Center, University of Texas Health Science Center at Houston, Houston, Texas
Relationship Disclosure: Dr Burish has received personal compensation for serving as a lecturer for the Midwest Pain Society and the North American Neuromodulation Society and has received research/grant support from the American Headache Society, the National Headache Foundation, and the Will Erwin Headache Research Foundation.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Burish discusses the unlabeled/investigational use of baclofen, corticosteroids, deep brain stimulation, lithium, occipital nerve stimulation, oxygen, sphenopalatine ganglion stimulation, sumatriptan, topiramate, valproate, verapamil, and zolmitriptan for the treatment of cluster headache; indomethacin, topiramate, and verapamil for the treatment of paroxysmal hemicrania; carbamazepine, duloxetine, gabapentin, lamotrigine, lidocaine, oxcarbazepine, and topiramate for the treatment of short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing; and celecoxib, gabapentin, ibuprofen, indomethacin, melatonin, occipital nerve stimulation, onabotulinum toxin injections, topiramate, and verapamil for the treatment of hemicrania continua.
Andrew Charles, MD
Professor of Neurology, Meyer and Renee Luskin Chair in Migraine and Headache Studies; Director, University of California Los Angeles Goldberg Migraine Program, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California
Relationship Disclosure: Dr Charles receives personal compensation for serving on the advisory boards of Alder BioPharmaceuticals, Inc; Biohaven Pharmaceutical; Eli Lilly and Company; and eNeura Inc. Dr Charles receives personal compensation for serving as associate editor of Cephalalgia; as CME program speaker of Medicom and Medlearning Group; and as a consultant for Amgen Inc. Dr Charles has served as an expert witness in legal proceedings for Milano & Wanat LLC.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Charles discusses the unlabeled/investigational use of ketamine for the treatment for migraine aura.
Denise E. Chou, MD
Global Medical Director, Neuroscience, Amgen Inc, Thousand Oaks, California
Relationship Disclosure: Dr Chou has received personal compensation for serving on the advisory boards of Allergan, Amgen Inc, Eli Lilly and Company, Pernix Therapeutics, and Teva Pharmaceutical Industries Ltd; as a speaker for the American Academy of Neurology, Medscape Inc, and the PeerView Institute; and has received research/grant support as a principal investigator for Alder BioPharmaceuticals, Inc; Capnia, Inc; CEFALY Technology; and Teva Pharmaceutical Industries Ltd. Dr Chou is an employee of Amgen Inc.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Chou discusses the unlabeled/investigational use of glucocorticoids for the treatment of giant cell arteritis and Tolosa-Hunt syndrome, indomethacin for the treatment of hemicrania continua, and nonsteroidal anti-infl ammatory drugs and oral or locally injected steroids for the treatment of primary trochlear headache (trochleitis).
Deborah I. Friedman, MD, MPH, FAAN
Professor, Department of Neurology and Neurotherapeutics, Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas
Relationship Disclosure: Dr Friedman has received personal compensation for serving on the advisory boards of Alder BioPharmaceuticals, Inc; Amgen Inc; Avanir Pharmaceuticals, Inc; Biohaven Pharmaceutical; ElectroCore, LLC; Supernus Pharmaceuticals, Inc; Teva Pharmaceutical Industries Ltd; and Zosano Pharma Corporation. Dr Friedman has received personal compensation for serving on the board of directors of the American Headache Society, as a contributing author for MedLink Neurology, and on the editorial board of Neurology Reviews. Dr Friedman has received personal compensation as a consultant for Avanir Pharmaceuticals, Inc; Biohaven Pharmaceutical; ElectroCore, LLC; Eli Lilly and Company; Promius Pharma, LLC; and Teva Pharmaceutical Industries Ltd and as a speaker for Allergan; Amgen Inc; Avanir Pharmaceuticals, Inc; ElectroCore, LLC; Supernus Pharmaceuticals, Inc; and Teva Pharmaceutical Industries Ltd. Dr Friedman has received research/grant support from Autonomic Technologies, Inc; Axon Optics; Eli Lilly and Company; Merck & Co, Inc; and Zosano Pharma Corporation. Dr Friedman has served as an expert witness in legal cases involving idiopathic intracranial hypertension.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Friedman discusses the unlabeled/investigational use of acetazolamide for the treatment of pseudotumor cerebri syndrome, the use of gadolinium for MRI myelography for the diagnosis of spontaneous intracranial hypotension, and the use of zonisamide for the treatment of associated headache.
Amy A. Gelfand, MD
Director of Pediatric Headache, Assistant Professor of Neurology and Pediatrics, University of California San Francisco, San Francisco, California
Relationship Disclosure: Dr Gelfand has received personal compensation for serving on the medical advisory board of eNeura Inc; as associate editor for JAMA Neurology; and as a consultant for Biohaven Pharmaceutical, Eli Lilly and Company, and Zosano Pharma Corporation. Dr Gelfand has received research/grant support from eNeura Inc, the Migraine Research Foundation, the National Institutes of Health/National Center for Advancing Translational Sciences, and the University of California San Francisco Weill Institute for the Neurosciences. Dr Gelfand has received publishing royalties from UpToDate, Inc and has received compensation as a legal consultant.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Gelfand discusses the unlabeled/investigational use of all listed medications for the treatment of headache in children and adolescents, with the exceptions of almotriptan oral tablets, sumatriptan/naproxen combination tablets, and zolmitriptan nasal spray for adolescents 12 to 17 years of age for the treatment of acute migraine as well as topiramate in adolescents 12 to 17 years of age for migraine prevention. Rizatriptan is labeled for acute migraine treatment in children age 6 and older.
Nazia Karsan, MBBS, MRCP
Neurology Fellow, Headache Group, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology, and Neuroscience; National Institute for Health Research and Wellcome Trust King’s Clinical Research Facility, King’s College London, London, United Kingdom
Relationship Disclosure: Dr Karsan has received personal compensation for serving as a speaker for Teva Pharmaceutical Industries Ltd and has received research/grant funding from the Association of British Neurologists/Guarantors of Brain Clinical Research Training Fellowship.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Karsan reports no disclosure.
Joseph S. Kass, MD, JD, FAAN
Associate Dean, Office of Student Affairs; Professor of Neurology, Psychiatry, and Medical Ethics; Director, Alzheimer’s Disease and Memory Disorders Center, Baylor College of Medicine; Chief of Neurology, Ben Taub General Hospital, Houston, Texas
Relationship Disclosure: Dr Kass serves as associate editor of ethical and medicolegal issues for Continuum, as an associate editor for Continuum Audio, as a neurology section editor of Ferri’s Clinical Advisor for Elsevier, and as co-editor of Neurology Secrets, Sixth Edition. Dr Kass has received personal compensation for CME lectures from Pri-Med Medical Group and has received personal compensation as a medicolegal consultant in legal cases involving criminal cases, malpractice, and personal injury.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Kass reports no disclosure.
Matthew S. Robbins, MD, FAAN, FAHS
Associate Professor of Neurology, Albert Einstein College of Medicine; Chief of Neurology, Jack D. Weiler Hospital; Director of Inpatient Services, Montefiore Headache Center; Associate Program Director, Neurology Residency, Montefi ore Medical Center, Bronx, New York
Relationship Disclosure: Dr Robbins has received personal compensation for serving as a section editor for Current Pain and Headache Reports and serves (without compensation) on the board of directors and as a member-at-large of the American Headache Society and as associate editor of Headache: The Journal of Head and Face Pain. Dr Robbins has received book royalties from John Wiley & Sons.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Robbins discusses the unlabeled/investigational use of medications and devices for the treatment of headache disorders in pregnant and breast-feeding women, including all analgesics, neuromodulation devices, preventive therapies, and triptans.
Rachel V. Rose, JD, MBA
Attorney, Rachel V. Rose Attorney at Law PLLC; Affiliated Faculty, Baylor College of Medicine, Houston, Texas
Relationship Disclosure: Ms Rose serves on the editorial board of BC Advantage.
Unlabeled Use of Products/Investigational Use Disclosure: Ms Rose reports no disclosure.
Todd J. Schwedt, MD, FAAN
Professor of Neurology, Mayo Clinic, Phoenix, Arizona
Relationship Disclosure: Dr Schwedt serves on the board of directors for the American Headache Society and the International Headache Society; receives personal compensation as associate editor for Cephalalgia, Headache, and Pain Medicine; and receives personal compensation as a consultant for Alder BioPharmaceuticals, Inc; Allergan; Amgen Inc; Autonomic Technologies, Inc; Avanir Pharmaceuticals, Inc; Dr. Reddy’s Laboratories Ltd; Eli Lilly and Company; Ipsen Bioscience, Inc; Nocira, LLC; Novartis AG; and Teva Pharmaceutical Industries Ltd. He has stock options in Aural Analytics; Nocira, LLC; and Second Opinion. Dr Schwedt has received research/grant support from the American Migraine Foundation, the National Institutes of Health, Patient-Centered Outcomes Research Institute, and the United States Department of Defense. Dr Schwedt has received publishing royalties from UpToDate, Inc.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Schwedt discusses the unlabeled/investigational use of numerous medications for the treatment of migraine; none of the therapies discussed are approved by the US Food and Drug Administration except for caloric vestibular stimulation, divalproex sodium, erenumab, propranolol, timolol, topiramate, transcranial magnetic stimulation, and transcutaneous supraorbital nerve stimulation for the treatment of migraine and the use of onabotulinumtoxinA for the treatment of chronic migraine.
Amaal Jilani Starling, MD, FAHS
Assistant Professor of Neurology, Mayo Clinic, Scottsdale, Arizona
Relationship Disclosure: Dr Starling has received personal compensation for serving on the medical advisory boards of Alder BioPharmaceuticals, Inc; Amgen Inc; Eli Lilly and Company; and eNeura Inc and as a consultant for Amgen Inc and Eli Lilly and Company. Dr Starling receives research/grant support from Mayo Clinic and the Migraine Research Foundation.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Starling discusses the unlabeled/investigational use of acetazolamide, beta-blockers including nadolol and propranolol, caffeine, celecoxib, clomipramine, clonazepam, cyclobenzaprine, ergotamine, fl unarizine, gabapentin, indomethacin, lithium, melatonin, nifedipine, nonsteroidal anti-infl ammatory drugs, onabotulinumtoxinA, topiramate, and tricyclic antidepressants including amitriptyline for the treatment of unusual headache disorders.
Stewart J. Tepper, MD, FAHS
Professor of Neurology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire
Relationship Disclosure: Dr Tepper has received personal compensation as editor-in-chief of the American Headache Society journal Headache Currents and has received personal compensation as a lecturer for CME. Dr Tepper has received personal compensation as a consultant for Acorda Therapeutics; Alder BioPharmaceuticals, Inc; Allergan; Amgen Inc; Autonomic Technologies, Inc; CEFALY Technology; Charleston Laboratories, Inc; DeepBench; Dr. Reddy’s Laboratories Ltd; ElectroCore, LLC; Eli Lilly and Company; eNeura Inc; Gerson Lehrman Group, Inc; Guidepoint Global, LLC; Impax; Neurolief Ltd; Novartis AG; Pfi zer Inc; Scion NeuroStim LLC; Slingshot Insights; Supernus Pharmaceuticals, Inc; Teva Pharmaceutical Industries Ltd; and Zosano Pharma Corporation. Dr Tepper receives research/grant support paid to his employer (no personal compensation) from Alder BioPharmaceuticals, Inc; Allergan; Amgen Inc; Autonomic Technologies, Inc; Avanir Pharmaceuticals, Inc; Dr. Reddy’s Laboratories Ltd; ElectroCore, LLC; eNeura Inc; Scion NeuroStim LLC; Teva Pharmaceutical Industries Ltd; and Zosano Pharma Corporation. Dr Tepper has stock options from Autonomic Technologies, Inc and receives royalties from Springer.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Tepper discusses the unlabeled/investigational use of all listed medications for the treatment of neuralgias.
Bert B. Vargas, MD, FAAN, FAHS
Associate Professor, University of Texas Southwestern Medical Center, Dallas, Texas
Relationship Disclosure: Dr Vargas has received personal compensation for serving on the advisory boards of Alder BioPharmaceuticals, Inc; Allergan; Amgen Inc; Avanir Pharmaceuticals, Inc; Eli Lilly and Company; Pernix Therapeutics; Teva Pharmaceutical Industries Ltd; and Upsher-Smith Laboratories, LLC; for serving on the speaker’s bureau of Amgen Inc and Avanir Pharmaceuticals, Inc; and has received travel compensation as an editor for Neurology Today.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Vargas discusses the unlabeled/investigational use acetaminophen, acetylsalicylic acid, dexketoprofen, diclofenac, dipyrone, droperidol, haloperidol, ibuprofen, ketorolac, lasmiditan, metoclopramide, naproxen, peripheral nerve block, prochlorperazine, and valproate for the acute treatment of migraine.
Self-Assessment and CME Test Writers
D. Joanne Lynn, MD, FAAN
Associate Dean for Student Life, Clinical Professor of Neurology, The Ohio State University College of Medicine, Columbus, Ohio
Relationship Disclosure: Dr Lynn receives book royalties from Lippincott Williams & Wilkins and holds stock in Abbott Laboratories; AbbVie Inc; Amgen Inc; Bristol-Myers Squibb Company; CVS Health Corporation; Express Scripts Holding Company; General Electric; Merck & Co, Inc; and Zimmer Biomet.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Lynn reports no disclosure.
Allison L. Weathers, MD, FAAN
Associate Chief Medical Information Officer, Cleveland Clinic; Assistant Professor, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio
Relationship Disclosure: Dr Weathers serves on the editorial board of Continuum and as chair of the adult neurosciences specialty steering board for Epic.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Weathers reports no disclosure.
