Surgical Therapies for Parkinson Disease

Ashley E. Rawls, MD, MS Movement Disorders p. 1301-1313 October 2022, Vol.28, No.5 doi: 10.1212/CON.0000000000001160
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PURPOSE OF REVIEW Parkinson disease (PD) is a progressive neurodegenerative disorder that is often difficult to manage with medications alone. This article reviews the current therapeutic surgical interventions for PD, patient selection criteria, timing of patient referral to surgical services, procedure overview, and future directions.

RECENT FINDINGS Adaptive, or closed-loop, deep brain stimulation is a promising therapy that can detect ongoing circuit changes and deliver appropriate stimulation based on the patient’s dominant symptom and level of dopaminergic medication.

SUMMARY Patients with PD can benefit from surgical interventions that can be added to their medication regimen. These patients should be referred to comprehensive centers that offer complete multidisciplinary screening evaluation to ensure appropriate patient selection and intervention selection. With the appropriate surgical intervention and continued management from their care team, patients with PD can maximize their quality of life.

Address correspondence to Dr Ashley E. Rawls, University of Florida Norman Fixel Institute for Neurological Diseases, 3009 SW Williston Rd, Gainesville, FL 32608, [email protected].

RELATIONSHIP DISCLOSURE: Dr Rawls has received personal compensation in the range of $500 to $4999 for serving as an editor, associate editor, or editorial advisory board member for JAMA Neurology and as a physician expert panelist with Mediflix, Inc.

UNLABELED USE OF PRODUCTS/INVESTIGATIONAL USE DISCLOSURE: Dr Rawls discusses the unlabeled/investigational use of closed-loop deep brain stimulation for the treatment of Parkinson disease.

© 2022 American Academy of Neurology.