Address correspondence to Dr J. Ricardo Carhuapoma, Johns Hopkins Hospital, 1800 Orleans St, Phipps 455, Baltimore, MD 21287, firstname.lastname@example.org.
RELATIONSHIP DISCLOSURE: Dr Ziai serves as an associate editor for Neurocritical Care, on an advisory board for C.R. Bard Inc, and has received personal compensation as a consultant for and research/grant support from HeadSense Medical Ltd. Dr Ziai has received grant support from the Johns Hopkins Anesthesiology and Critical Care Medicine (ACCM) Stimulating and Advancing ACCM Research (StAAR) program and from the National Institutes of Health (5U01NS062851, 1U01NS08082). Dr Carhuapoma reports no disclosure.
UNLABELED USE OF PRODUCTS/INVESTIGATIONAL USE DISCLOSURE: Drs Ziai and Carhuapoma discuss the unlabeled/investigational use of alteplase for the treatment of intracerebral hemorrhage and discuss the use of several devices, including ultrasound microcatheters, sonothrombolysis for minimally invasive subcortical parafascicular transsulcal access for clot evacuation (MiSPACE), and the stereotactic mechanical (suction/vibration/aspiration) thrombolytic technique for minimally invasive evacuation of intracerebral hemorrhage.
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