Management of Intracranial Pressure

W. David Freeman, MD, FSNS, FAAN Neurocritical Care p. 1299-1323 October 2015, Vol.21, No.5 doi: 10.1212/CON.0000000000000235
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Purpose of Review:: Intracranial pressure (ICP) can be elevated in traumatic brain injury, large artery acute ischemic stroke, intracranial hemorrhage, intracranial neoplasms, and diffuse cerebral disorders such as meningitis, encephalitis, and acute hepatic failure. Raised ICP is also known as intracranial hypertension and is defined as a sustained ICP of greater than 20 mm Hg.

Recent Findings:: ICP must be measured through an invasive brain catheter, typically an external ventricular catheter that can drain CSF and measure ICP, or through an intraparenchymal ICP probe. Proper recognition of the clinical signs of elevated ICP is essential for timely diagnosis and treatment to prevent cerebral hypoperfusion and possible brain death. Clinical signs of elevated ICP include headache, papilledema, nausea, and vomiting in the early phases, followed by stupor and coma, pupillary changes, hemiparesis or quadriparesis, posturing and respiratory abnormalities, and eventually cardiopulmonary arrest.

Summary:: Management of elevated ICP is, in part, dependent on the underlying cause. Medical options for treating elevated ICP include head of bed elevation, IV mannitol, hypertonic saline, transient hyperventilation, barbiturates, and, if ICP remains refractory, sedation, endotracheal intubation, mechanical ventilation, and neuromuscular paralysis. Surgical options include CSF drainage if hydrocephalus is present and decompression of a surgical lesion, such as an intracranial hematoma/large infarct or tumor, if the patient’s condition is deemed salvageable. Future research should continue investigating medical and surgical options for the treatment of raised ICP, such as hypothermia, drugs that reduce cerebral edema, and operations aimed at reducing intracranial mass effect.

Address correspondence to Dr W. David Freeman, Mayo Clinic College of Medicine, 4500 San Pablo Rd, Cannaday 2 East Neurology, Jacksonville, FL 32224,

Relationship Disclosure: Dr Freeman receives book royalties from Cambridge University Press and Oxford University Press.

Unlabeled Use of Products/Investigational Use Disclosure: Dr Freeman reports no disclosure.

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© 2015 American Academy of Neurology