Address correspondence to Dr Francois Bethoux, Mellen Center for MS Treatment and Research, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk U10, Cleveland, OH 44195, firstname.lastname@example.org.
Relationship Disclosure: Dr Bethoux has served as a speaker for Acorda Therapeutics, Allergan, Inc, Biogen Idec, and Medtronic, Inc and serves on scientific advisory boards for Acorda Therapeutic and Merz Pharma. Dr Bethoux serves on the editorial board of International Journal of MS Care, published by The Consortium of MS Centers. Dr Bethoux has received research support from Acorda Therapeutics for studies and clinical trials of dalfampridine; from Innovative Neurotronics, Inc, for a trial of the WalkAide device; and from Merz Pharma for a study of Xeomin.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Bethoux discusses the unlabeled use of benzodiazepines, cannabinoids, and botulinum toxin injections for the treatment of lower extremity spasticity; antiepileptics and tricyclic antidepressants for neuropathic pain; and amantadine, modafinil, and armodafinil for fatigue related to multiple sclerosis.