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Phibbs, Fenna T.; Hedera, Peter

doi: 10.1212/01.CON.0000348901.09963.f5

The significant contribution of genetic research has resulted in substantial progress in our understanding of the pathophysiology of movement disorders. This will allow for earlier diagnosis of patients with the potential to influence future therapeutics. However, given the complicated patterns of inheritance and consequences for successive generations, a review of the current state of knowledge as well as basic genetic principles is important. In this review we will discuss current classification systems, and clinical and neuropathologic features of the major genetic etiologies for Parkinson disease, dystonia, chorea, and ataxia.

Relationship Disclosure: Drs Phibbs and Hedera have nothing to disclose.

Unlabeled Use of Products/Investigational Use Disclosure: Drs Phibbs and Hedera have nothing to disclose.

© 2010 American Academy of Neurology
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