Hereditary myelopathies are a diverse group of disorders in which major aspects of the clinical syndrome involve spinal cord structures. Hereditary myelopathic syndromes can be recognized as four clinical paradigms: (1) spinocerebellar ataxia, (2) motor neuron disorder, (3) leukodystrophy, and (4) distal motor-sensory axonopathy. This review illustrates these hereditary myelopathy paradigms with clinical examples with an emphasis on clinical recognition and differential diagnosis.
Relationship Disclosure: Dr Fink has received personal compensation from Athena Diagnostics, Inc. Dr Fink has received royalty payments for atlastin and NIPA1 patents.
Unlabeled Use of Products/Investigational Use Disclosure: Dr Fink has nothing to disclose.