Adult-onset dementias are complex traits with environmental, genetic and mixed genetic, and environmental causes. Among the genetic causes, several different genes can cause the same disease phenotype either as separate causes (ie, as single gene defects typically inherited as autosomal dominant traits) or as cumulative effects from several genes, each with small effect sizes, contributing to the overall risk. This chapter describes the genes that have been identified as risk factors for adult-onset degenerative dementias. This review also describes how these genes can be used in clinical practice.
Relationship Disclosure: Dr St George-Hyslop has received personal compensation for a single appearance at scientific review panels at Schering-Plough and AstraZeneca.
Unlabeled Use of Products/Investigational Use Disclosure: Dr St George-Hyslop has nothing to disclose.