POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDERS OF THE CENTRAL NERVOUS SYSTEM

Brian Patrick O'Neill; David Schiff Neurologic Complications of Organ Transplantation p. 48-60 April 2004, Vol.10, No.2 doi: 10.1212/01.CON.0000290712.18583.6f
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Post-transplant lymphoproliferative disorders (PTLD) are invariably Epstein-Barr virus-driven expansions of germinal center-derived B-lymphocytes occurring in organ transplant recipients. PTLD of the central nervous system (CNS) is a less common variant, but its importance is far out of proportion to the impact of disease in the more common extranodal sites. Histologic confirmation is necessary for precise diagnosis and management decisions since opportunistic infections and neurotoxicity of therapy may mimic the magnetic resonance findings of CNS PTLD. An approach to the patient is discussed.

© 2004 American Academy of Neurology