Neuromuscular complications occur in organ transplant recipients as a result of critical illness, drug toxicity, host-immune mechanisms, and, rarely, opportunistic infections. Acute disorders include critical illness myopathy, critical illness polyneuropathy, an acute demyelinating polyneuropathy, and mononeuropathies. Subacute to chronic processes include toxic myopathy and neuropathy, polymyositis, and myasthenia gravis. Although the predispositions may vary, the approach to evaluating these disorders and their treatments is often similar to those undertaken in the nontransplant population.