Corticobasal degeneration (CBD), a tau-related neurodegenerative disease, is characterized by limb rigidity, dystonia, myoclonus, apraxia, and cognitive deficits. We report a patient with probable corticobasal syndrome, a major phenotype of CBD, who revealed both lower vertical and proximal radial attentional neglect on line bisection tests. Brain imaging revealed bilateral parietal atrophy with hypometabolism in the bilateral parietal, dorsolateral prefrontal, and premotor cortices. Bilateral impairment in the dorsal attentional network reduces the allocation of spatial attention to lower and proximal space, causing lower vertical and proximal radial attentional neglect. Screening for various types of spatial neglect may be important in tailoring management and rehabilitation strategies for patients with CBD.
*Division of Cognitive and Behavioral Neurology, Department of Neurology, University of Florida College of Medicine
†Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida
Present address: Parunyou Julayanont, MD, Department of Neurology, Texas Tech University Health Sciences Center, School of Medicine, 3601 4th Street, MS 8321, Lubbock, Texas 79430-8321.
The authors declare no conflicts of interest.
Correspondence: Parunyou Julayanont, MD, Department of Neurology, Texas Tech University Health Sciences Center, School of Medicine, 3601 4th Street, MS 8321, Lubbock, Texas 79430-8321 (email: email@example.com).
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Received April 25, 2019
Accepted June 24, 2019