Case ReportsA Degenerative Form of Mixed Transcortical AphasiaSaadatpour, Leila MD*; Tariq, Usama MBBS*; Parker, Alicia MD*; Doty, Leilani PhD*,†; Heilman, Kenneth M. MD*,†,‡Author Information *Department of Neurology, University of Florida, Gainesville, Florida †National Institutes of Health, Florida ADRC (Alzheimer’s Disease Research Center), Gainesville, Florida ‡Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida The authors declare no conflicts of interest. Written work prepared by employees of the Federal Government as part of their official duties is, under the U.S. Copyright Act, a “work of the United States Government” for which copyright protection under Title 17 of the United States Code is not available. As such, copyright does not extend to the contributions of employees of the Federal Government. Correspondence: Leila Saadatpour, MD, 1149 Newell Dr, McKnight Brain Institute, Department of Neurology, Room L3-100, Gainesville, Florida 32611 (e-mail: Leilasaadatpour@ufl.edu). Cognitive And Behavioral Neurology: March 2018 - Volume 31 - Issue 1 - p 18-22 doi: 10.1097/WNN.0000000000000144 Buy Metrics Abstract Mixed transcortical aphasia (MTA) is characterized by decreased spontaneous speech, impaired naming, and poor comprehension, but with intact repetition. MTA has been reported to be the sequela of left hemisphere watershed infarction that isolates Wernicke’s perisylvian arc. We report a 55-year-old right-handed woman who began having word-finding difficulty and then gradually developed impaired spontaneous speech, comprehension, and naming, but with intact repetition. Magnetic resonance imaging showed atrophy in the left frontal, parietal, and temporal lobes. This patient demonstrates that MTA can occur as a result of neurodegenerative disease. Further research is needed to learn whether progressive MTA is a late stage of primary progressive aphasia, examine the neuropathology associated with this syndrome, and identify treatment strategies.