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The Effect of Ropinirole on Apathy and Depression After Herpes Encephalitis

Kohno, Naoto MD*; Nabika, Yoko MD; Toyoda, Genya MD*; Bokura, Hirokazu MD, PhD*; Nagata, Tomoko MD, PhD; Yamaguchi, Shuhei MD, PhD

Cognitive and Behavioral Neurology: June 2012 - Volume 25 - Issue 2 - p 98–102
doi: 10.1097/WNN.0b013e3182591ea5
Case Reports

We describe a 76-year-old man with herpes encephalitis whose symptom of severe apathy was improved by the dopamine D2/D3 receptor agonist ropinirole. Brain magnetic resonance imaging had shown lesions in the patient's right mesial temporal cortex, right insula, and bilateral medial frontal regions. During treatment with acyclovir, he had developed severe apathy and depression. On neuropsychological assessment, he scored 21/30 points on the Mini-Mental State Examination, 30/42 on the Starkstein Apathy Scale (cutoff score =16), and 59/80 on the Zung Self-Rating Depression Scale (cutoff score=40). We then started him on ropinirole 0.25 mg/day. Over the next 10 days, his apathy and depression gradually improved. On day 10 of treatment, follow-up testing showed that his Apathy Scale score had improved to 25 points. This case suggests that a low dose of a dopamine receptor agonist may be an effective treatment for patients who develop apathy and depression after encephalitis.

Departments of *Neurology and

Rehabilitation Medicine, Shimane Prefectural Central Hospital, Himebara, Izumo, Japan

Department of Neurology, Shimane University, Enya, Izumo, Japan

The authors declare no conflicts of interest.

Reprints: Naoto Kohno, MD, Department of Neurology, Shimane Prefectural Central Hospital, Himebara 4-1-1, Izumo 693-8555, Japan (e-mail:

Received February 6, 2011

Accepted February 6, 2012

© 2012 Lippincott Williams & Wilkins, Inc.