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Five-year Survival After Helicobacter pylori Eradication in Alzheimer Disease Patients

Kountouras, Jannis MD, PhD*; Boziki, Marina MD; Gavalas, Emmanouel MD*; Zavos, Christos MD*; Deretzi, Georgia MD, PhD; Chatzigeorgiou, Stavros MD*; Katsinelos, Panagiotis MD, PhD*; Grigoriadis, Nikolaos MD, PhD; Giartza-Taxidou, Evangelia MD, PhD*; Venizelos, Ioannis MD, PhD*

Cognitive and Behavioral Neurology: September 2010 - Volume 23 - Issue 3 - p 199-204
doi: 10.1097/WNN.0b013e3181df3034
Original Studies

Background Alzheimer disease (AD) is a progressive, fatal neurodegenerative condition.

Objective We tested the hypothesis that eradication of Helicobacter pylori infection (Hp-I) could improve survival in a Greek cohort of AD patients, in a 5-year follow-up.

Method Forty-six patients diagnosed with probable AD were enrolled in the analysis. Study population was classified into 3 groups: patients for whom Hp eradication treatment was successful; those for whom eradication of Hp had failed, they refused, and/or were noncompliant with eradication therapy; and those who were Hp negative at baseline. Cox proportional hazards model was built with all-cause mortality as the dichotomous outcome.

Results During the 5-year follow-up [47.19±15.11 mo (range 12 to 60)], overall 21 patients died and 25 patients remained alive. Patients who died were older and exhibited lower mean MMSE score compared with the patients still alive. Successful eradication of Hp-I was associated with a significantly lower mortality risk [HR (95% CI)=0.287 (0.114-0.725), P=0.008]. The results were similar in adjusted and unadjusted models, for age and MMSE at baseline.

Conclusion Hp eradication regimen in AD patients is associated with a higher 5-year survival rate.

*Department of Gastroenterology, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital

Second Neurological Clinic, “AHEPA” General Hospital, Aristotle University of Thessaloniki

Neurological Clinic, “Papageorgiou” General Hospital, Thessaloniki, Greece

Reprints: Jannis Kountouras, MD, PhD, Department of Gastroenterology, Aristotle University of Thessaloniki, Ippokration Hospital 8 Fanariou Street, Byzantio, Thessaloniki, 551 33, Macedonia, Greece (e-mail:

Received for publication November 20, 2009; accepted March 14, 2010

© 2010 Lippincott Williams & Wilkins, Inc.