Septo-optic Dysplasia and Psychiatric Disorders: A Case ReportBini, Paola MD*; Montalbetti, Lorenza MD*; Tosca, Pietro MD*; Ratti, Maria Teresa PhD*; Uggetti, Carla MD†; Moglia, Arrigo MD*; Costa, Alfredo MD‡Cognitive and Behavioral Neurology: December 2008 - Volume 21 - Issue 4 - p 254-257 doi: 10.1097/WNN.0b013e3181910f02 Case Reports Abstract Author Information Background Septo-optic dysplasia, a variable combination of abnormalities of cerebral midline structures, is a clinically heterogeneous syndrome in which the midline defects may be implicated in psychiatric disturbances. Objective To describe a case of septo-optic dysplasia associated with depression and psychosis and to discuss the role of these developmental abnormalities in psychiatric disturbances. Methods The patient's clinico-anamnestic, neuroradiologic, neuropsychiatric, endocrinologic, ophthalmologic, and genetic profile was evaluated. Conclusions Developmental abnormalities due to disruption of the complex neural network linking the septum pellucidum with other limbic structures may have been involved in the affective and psychotic disturbances observed in our patient. Departments of *Behavioural Neurology †Neuroradiology ‡Section of Neurobiological Psychiatry, UCADH, Institute of Neurology IRCCS C. Mondino, University of Pavia, Italy Reprints: Paola Bini, MD, Department of Behavioural Neurology, Institute of Neurology IRCCS C. Mondino, via Mondino 2, Pavia 27100, Italy (e-mail email@example.com). Received for publication March 17, 2008; accepted September 30, 2008 © 2008 Lippincott Williams & Wilkins, Inc.