Case ReportAudiovisual Peduncular Hallucinations: A Release of Cross-Modal Integration Sites?Taylor, Kirsten I PhD; Brugger, Peter PhD; Schwarz, Urs MDAuthor Information Department of Neurology, University Hospital Zürich, Zürich, Switzerland. Received for publication May 18, 2004; revised November 23, 2004; accepted December 16, 2004. This study was supported by a grant from the Roche Research and Hartmann Müller Foundations. Dr. Taylor's current address is Centre for Speech and Language, University of Cambridge, Cambridge, UK, and Memory Clinic-NPZ, University Hospital, Basel, Switzerland. Reprints: Dr. Urs Schwarz, Department of Neurology, University Hospital Zürich, Frauenklinikstrasse 26, CH-8091 Zürich, Switzerland (e-mail: firstname.lastname@example.org). Cognitive and Behavioral Neurology: June 2005 - Volume 18 - Issue 2 - p 135-136 doi: 10.1097/01.wnn.0000155105.84123.1c Buy Metrics Abstract We report the case of a patient with multiple sclerosis with congruent visual and auditory hallucinations of deceased familiar persons that lasted continuously for several days. Magnetic resonance imaging revealed an isolated, predominantly left-sided lesion in the periaqueductal segment of the mesencephalon. We propose that these hallucinations represent a bimodal variant of classic peduncular hallucinations, brought about by a deregulation of modulatory superior collicular activity and a release of cross-modal integrative functions of the superior temporal sulcus. © 2005 Lippincott Williams & Wilkins, Inc.