To longitudinally assess the prevalence of depression
following carbon monoxide
(CO) poisoning and to assess the contributions of mode of poisoning (accidental versus suicide attempt), cognitive sequelae
, and oxygen dose (hyperbaric oxygen
versus normobaric oxygen) to depression
CO is the most common cause of poisoning in the United States and may result in neuropathologic changes and cognitive and neurologic sequelae, yet little is known regarding affective outcomes.
We prospectively assessed affect
in 127 CO-poisoned patients. Self-report inventories of depression
were administered at 6 weeks and at 6 and 12 months post CO poisoning. The primary outcome was prevalence of depression
at 6 weeks. To determine the effect of mode of poisoning, cognitive sequelae
, and oxygen dose, odds ratio estimates were calculated at all three times using logistic regression.
were present in 45% of patients at 6 weeks, 44% at 6 months, and 43% at 12 months. Patients with suicide attempt and cognitive sequelae
had higher prevalence of depression
at 6 weeks. At 12 months, there were no differences in depression
regardless of mode of poisoning, presence of cognitive sequelae
, or oxygen dose.
CO poisoning results in significant depression
that persist to at least 12 months. Patients with cognitive sequelae
and suicide attempt had a higher rate of depression
at 6 weeks but not at 12 months. Clinicians need to be aware of affective morbidity following CO poisoning and remain vigilant about CO prevention.