ORIGINAL ARTICLE: PDF OnlyLesion Location and Depression in Hospitalized Stroke Patients Evidence Supporting a Specific Relationship in the Left HemisphereMorris, Philip L. P. M.D., Ph.D; Robinson, Robert G. M.D*; Raphael, Beverley M.D.† Author Information Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland, Baltimore, Maryland; *Department of Psychiatry, University of Iowa, Iowa City, Iowa, U.S.A., †Department of Psychiatry, University of Queensland, Brisbane, Australia Neuropsychiatry, Neuropsychology & Behavioral Neurology: April 1992 - Volume 5 - Issue 2 - p 75-82 Buy Abstract The study of post-stroke depression affords an opportunity to examine the relationship of mood to cerebral lesion characteristics defined by computed tomography (CT). We undertook a study of this relationship in 35 hospitalized Australian patients. The results provided evidence that anterior lesion location in the left hemisphere was associated with both a diagnosis of depression and the severity of depressive symptoms—but only after the influence of pre-stroke vulnerability to depression was removed. Among patients without a prior history of affective disorder, severity of depressive symptoms was significantly correlated (r = −0.872; p = 0.0001) with anterior location among left but not right hemisphere lesions. The findings suggest that, although lesion location may be an etiological factor in some post-stroke depressions, other variables that increase vulnerability to depression should be controlled for in future studies of this topic. © Lippincott-Raven Publishers.