REVIEWUpdate on classification of oncocytic neoplasms of the kidneyOszwald, Andréa; Wasinger, Gabriela; Zisser, Luciab; Compérat, Evaa Author Information aDepartment of Pathology bDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna Correspondence to Eva Compérat, Department of Pathology, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria. Tel: +43 1 40400 36860; e-mail: [email protected] Current Opinion in Urology ():10.1097/MOU.0000000000001079, January 23, 2023. | DOI: 10.1097/MOU.0000000000001079 Buy PAP Metrics Abstract Purpose of the review This review provides a summary of recent developments in classification of renal oncocytic neoplasms that were incorporated in the fifth edition WHO classification of renal tumors, released in 2022. Recent findings Besides the distinct entities of renal oncocytoma and chromophobe renal cell carcinoma, the WHO now acknowledges a heterogeneous group of oncocytic tumors of the kidney that can be reported as ‘oncocytic renal neoplasms of low malignant potential’. Case series by multiple institutions have revealed recurrent patterns of morphological features, protein marker expression, and genetic alterations within these neoplasms that may permit further subclassification in the future. Summary The new classification system provides pathologists with the opportunity to simplify the diagnostic workup and reporting of morphologically equivocal oncocytic neoplasms. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.