REVIEWTransurethral resection of bladder cancer with or without fluorescenceHorňák, Jakub; Brisuda, Antonín; Babjuk, Marek Author Information Department of Urology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic Correspondence to MUDr. Jakub Horňák, Urologická klinika 2.LF UK a FN Motol, V Úvalu 84, 150 06 Praha 5, Czech Republic Tel: +420 224 434 801; e-mail: [email protected] Current Opinion in Urology ():10.1097/MOU.0000000000001071, January 12, 2023. | DOI: 10.1097/MOU.0000000000001071 Buy PAP Metrics Abstract Purpose of review Transurethral resection of bladder cancer (TURBT) is in its standard form an inherently imperfect technique. Fluorescence-guided photodynamic diagnosis (PDD) represents one way to improve the outcome by enhancing tumour detection. Fluorescence has been used in connection with bladder cancer since the 1970s, with a number of studies being published since then. However, the method is still not recommended as a standard part of TURBT mainly because of the limited level of evidence of concerned studies, questionable cost-effectiveness and even contradictory results. The review lists the latest articles covering this topic. Recent findings Several recently published meta-analyses reviewed a series of randomized controlled trials (RCTs) concerning PDD assisted TURBT. Results were generally supporting the positive effect on reduction of recurrence rate. However, the mentioned meta-analyses are overlapping in terms of reviewed RCT that provide only a low level of evidence according to a recent Cochrane review. Supposed limitations of PDD (timing of the procedure, low specificity) and possible solutions are also covered. Summary Most of the published data confirmed reduced early recurrence rate after PDD assisted TURBT comparing to standard TURBT. Its impact on late recurrence rate, progression rate or cost-effectiveness has not been sufficiently demonstrated. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.