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Perioperative systemic therapy for bladder cancer

Eulitt, Patrick J.a; Bjurlin, Marc A.b,c; Milowsky, Matthew I.a,c

doi: 10.1097/MOU.0000000000000600
BLADDER CANCER: Edited by Siamak Daneshmand

Purpose of review Recent advances in research related to biomarkers and immunotherapy has the potential to transform the landscape for the use of perioperative systemic therapy in patients with bladder cancer.

Recent findings Predictive biomarkers including DNA damage repair genes and gene expression profiling may soon lead to better selection of patients for neoadjuvant cisplatin-based chemotherapy. Success of immunotherapy for the treatment of metastatic bladder cancer has led to promising trials exploring immunotherapy in muscle-invasive disease.

Summary Current trials employing predictive biomarkers as well as those using immunotherapy have the potential to significantly improve the outcome of patients with muscle-invasive bladder cancer.

aDivision of Hematology/Oncology, Department of Medicine

bDepartment of Urology

cLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA

Correspondence to Matthew I. Milowsky, MD, Division of Hematology/Oncology, Department of Medicine, University of North Carolina, 170 Manning Drive, CB #7305, Chapel Hill, NC 27599, USA. Tel: +1 919 843 7942; fax: +1 919 966 6735; e-mail:

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