NON-MUSCLE INVASIVE BLADDER CANCER: Edited by Ashish M. Kamat and Paolo GonteroBiology of nonmuscle-invasive bladder cancer pathology, genomic implications, and immunologyDyrskjøt, Larsa; Ingersoll, Molly A.b,cAuthor Information aDepartment of Molecular Medicine, Aarhus University Hospital, Aarhus N, Aarhus, Denmark bDepartment of Immunology, Institut Pasteur cINSERM U1223, Paris, France Correspondence to Lars Dyrskjøt, PhD, Department of Molecular Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Aarhus, Denmark. Tel: +45 78455320; e-mail: firstname.lastname@example.org Current Opinion in Urology: November 2018 - Volume 28 - Issue 6 - p 598-603 doi: 10.1097/MOU.0000000000000543 Buy Metrics Abstract Purpose of review Despite that nearly 75% of bladder cancer patients are diagnosed with nonmuscle-invasive disease, our understanding of the biological landscape in bladder cancer is primarily within the context of muscle-invasive bladder cancer. More recent studies addressing the genomic changes and immunology of nonmuscle-invasive bladder cancer (NMIBC) have helped to extend our understanding of this prevalent disease. Recent findings Genomic studies reveal that NMIBC possesses complexity that can be defined by specific gene expression signatures and has helped to define subsets within this disease. These subsets possess different risk profiles that may impact treatment decisions. In addition, the baseline or posttreatment immunological response to the growing tumor may help to inform whether a specific NMIBC subset is likely to progress. Summary Findings from studies addressing the molecular landscape of NMIBC may help to establish parameters for stratifying patient risk within this disease as well as establish novel or targeted treatment strategies. Inclusion of information about the immune response within tumors will likely contribute to defining the relative risk and treatment strategy for these patients. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.